Amino Acid Transport Models: Renal Resorption and Resistance to Metabolic Attack
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چکیده
منابع مشابه
Amino acid transport across mammalian intestinal and renal epithelia.
The transport of amino acids in kidney and intestine is critical for the supply of amino acids to all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number of inherited disorders affecting amino acid transport in epithelial cells, such as cystinuria, lysinuric protein intolerance, Hartnup disorder, iminoglycinuria, dicarboxylic aminoaciduria, and some other le...
متن کاملRegulation of renal amino acid transporters during metabolic acidosis.
The kidney plays a major role in acid-base homeostasis by adapting the excretion of acid equivalents to dietary intake and metabolism. Urinary acid excretion is mediated by the secretion of protons and titratable acids, particularly ammonia. NH(3) is synthesized in proximal tubule cells from glutamine taken up via specific amino acid transporters. We tested whether kidney amino acid transporter...
متن کاملCongenital abnormalities of amino acid transport in renal tubules.
ADDRESS: 219 Bryant Street, Buffalo 22, New York. V ARLETLES of syndromes have been described in which an abnormal amount of organic acid appears in the urine. In many of those syndromes which have been carefully studied, amino acids appear to constitute the major portion of organic acids. This probably is the result of the development of adequate methodology for the determination of amino acid...
متن کاملPlacental amino acid transport.
Normal fetal growth and development depend on a continuous supply of amino acids from the mother to the fetus. The placenta is responsible for the transfer of amino acids between the two circulations. The human placenta is hemomonochorial, meaning that the maternal and fetal circulations are separated by a single layer of polarized epithelium called the syncytiotrophoblast, which is in direct c...
متن کاملAmino Acid Transport
I[I. Place of co-transport with Na ÷ . . . . . . . . . . . . . . . . . . . . . . . . . 489 A. Must the energy for Na+-dependent, uphill amino acid transport be channeled through alkali-metal gradients? . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 B. Attempts to eliminate experimentally the alkali-metal ion gradients without dissipating other forms of transport-related energy storag...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)60309-6